Dr. Paavas Sharma holds a Bachelor's degree in Dental Surgery from Manipal Academy of Higher Education. In her journey, she has garnered numerous accolades for her creative writing. Proficient in both English and Hindi, she particularly enjoys delving into topics related to sexual and dental health and possesses experience in writing about oncology. Dr. Paavas has 3 years of professional writing experience and was also involved in editorial teams for magazines since her school and college days. Apart from writing she consistently seeks opportunities for personal expression and enjoyment, whether it's cooking, Netflix sessions or indulging in crafts.
Our experts continually monitor the health and wellness space, and we update our articles when new information became available.
Updated on 24th February 2025
"The following blog article provides general information and insights on various topics. However, it is important to note that the information presented is not intended as professional advice in any specific field or area. The content of this blog is for general educational and informational purposes only.
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Trazodone is a widely used oral antidepressant. But did you know it’s also commonly prescribed off-label for conditions like insomnia, PTSD, and fibromyalgia? While trazodone can be helpful, it’s natural to wonder about potential side effects—especially when it comes to sexual health.
Talking about sexual side effects can feel awkward, but it’s an important part of understanding your medication. Let’s break down what you need to know about how trazodone might affect your sex life.
Yes, trazodone can cause sexual side effects, though they tend to be less common compared to certain other antidepressants, such as selective serotonin reuptake inhibitors (SSRIs). However, the way trazodone affects sexual function isn’t the same for everyone—it can vary based on individual physiology, dosage, and underlying health conditions.
Some people may experience changes in libido, while others might notice issues related to arousal, orgasm, or physical responses. Interestingly, trazodone has also been explored as a potential solution for sexual dysfunction caused by other antidepressants, making its effects complex and highly individualized.[1]
The impact of trazodone on men’s sexual health is mixed. Some men report a decrease in libido (sex drive), while others notice an increase. Other potential effects include:
Priapism is rare but serious. If untreated, it can lead to permanent damage. People with conditions like leukemia, sickle cell anemia, or Peyronie’s disease may have a higher risk. Be sure to discuss your medical history with your doctor before starting trazodone.
Women can also experience sexual side effects from trazodone. As with men, the effects vary—some report an increase in libido, while others notice a decrease. Other potential effects include:
If you experience clitorism, it’s best to seek medical care, as its long-term effects are not well understood.
Sexual side effects from antidepressants can be frustrating, but they don’t always mean you need to stop the medication. Sometimes, adjusting the dose, switching medications, or incorporating lifestyle changes can make a big difference. Open communication with your doctor is key.
Sexual side effects from trazodone appear to be uncommon. Most data comes from case reports rather than large-scale studies. In clinical trials:
Interestingly, trazodone might actually improve arousal rather than reduce it. Some research suggests that it could help counteract sexual dysfunction caused by SSRIs. Additionally, low-dose trazodone has been explored as a potential treatment for hypoactive sexual desire disorder (low sex drive).
Some sexual side effects may improve over time as your body adjusts to the medication, but there’s no guarantee. The extent to which these effects diminish varies from person to person. If sexual issues persist or become bothersome, your doctor may suggest adjusting the dosage, switching medications, or exploring other solutions to help manage the symptoms.
It’s also important to note that sexual dysfunction is often linked to depression and anxiety—conditions that trazodone treats. In some cases, staying on the medication for a while may actually lead to an improvement in sexual health as mental well-being stabilizes. However, if sexual side effects negatively impact your quality of life, discussing alternative options with your healthcare provider can help you find a better balance between mental health treatment and sexual function.
If you notice sexual side effects from trazodone, don’t hesitate to talk to your doctor. It might feel uncomfortable, but they’re there to help. Your doctor can assess whether a dosage adjustment, medication switch, or other strategy is needed.
What you shouldn’t do:
What you can do:
Certain sexual side effects, like priapism in men or clitorism in women, require immediate medical attention. These conditions can lead to long-term damage if not treated promptly. If you experience them, go to the emergency room and inform medical staff about the medications you’re taking.
Afterward, follow up with your doctor to discuss whether switching medications might be a better option for you.
Compared to other antidepressants, trazodone has a lower risk of causing sexual dysfunction. However, the risk of priapism—though rare—is considered higher with trazodone than with most other antidepressants.
One study found that trazodone caused fewer sexual side effects than fluoxetine (Prozac) and sertraline (Zoloft). In fact, it may even be used to improve sexual dysfunction caused by other antidepressants.
That said, everyone responds differently to medications. While some people experience no issues at all, others might find that trazodone affects their sexual health. If you’re concerned, talk to your doctor to find the best treatment plan for you.
